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mhqE [2018-02-08T11:12:27.000Z]
function
resistance to methyl hydroquinone and catechol
product
dioxygenase/glyoxalase
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]Gene
Coordinates
2,129,082 → 2,129,993
The protein
Paralogous protein(s)
[protein|7334017333600B876030056BE9247AD4E8996A1D|MhqA], [protein|ACAFB2072E74CC059B492A31EF492028B96C569F|MhqO]Structure
[PDB|3OAJ] ([protein|ACAFB2072E74CC059B492A31EF492028B96C569F|MhqO], 48% identical residues)[SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operons
genes
[gene|A1CB3DCF2EC78B9B0585CA6AC6F5BB37B8AF0208|mhqE]-[gene|43CD556065D2EF14365C78E014B7B2051CA0C78F|mhqD]
description
[Pubmed|17725564]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|17725564], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]regulatory mechanism
[protein|997B828A99D6D8460712C18ED0CE566B285C22DC|MhqR]: repression, [Pubmed|17725564], in [regulon|997B828A99D6D8460712C18ED0CE566B285C22DC|MhqR regulon]regulation
induced by 2-methylhydroquinone ([protein|search|MhqR]) [Pubmed|17725564]view in new tabBiological materials
Mutant
MGNA-B436 (yodE::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1435 NBRP B. subtilis, Japan]BKE19570 (Δ[gene|A1CB3DCF2EC78B9B0585CA6AC6F5BB37B8AF0208|mhqE]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE19570 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTCTCACTCCTATTTA, downstream forward: _UP4_GAACTTTAAAAGGGGGAATTBKK19570 (Δ[gene|A1CB3DCF2EC78B9B0585CA6AC6F5BB37B8AF0208|mhqE]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK19570 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTCTCACTCCTATTTA, downstream forward: _UP4_GAACTTTAAAAGGGGGAATTReferences
